Research Papers

Moningi S, Ho J, Proudfoot J, Sutera P, Deek MP, Phillips R, Rana ZH, Molitoris JK, Kwok Y, Mishra MV, Spina CS, Engelman A, Ross AE, Liu Y, Davicioni E, Jia AY, Spratt DE, Leapman MS, Tran PT. Examination of Decipher Prostate Genomic Classifier in patients with de novo metastatic disease from a large scale real-world clinical and transcriptomic data linkage. International Journal of Radiation Oncology, Biology, Physics. 2024;120(2):S134–S135. doi: 10.1016/j.ijrobp.2024.07.243.

Alì A, Leibowitz D, Bhatt N, Doubrovin M, Spina CS, Bates-Pappas GE, Taub RN, McKiernan JM, Mintz A, Molotkov A. Preliminary efficacy of [90Y]DOTA-biotin-avidin radiotherapy against non-muscle invasive bladder cancer. European Journal of Nuclear Medicine and Molecular Imaging. 2023;50(3):692–700. doi: 10.1007/s00259-022-06027-w.

Ager CR, Zhang M, Chaimowitz M, Bansal S, Tagore S, Obradovic A, Jugler C, Rogava M, Melms JC, McCann P, Spina C, Drake CG, Dallos MC, Izar B. KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response. Journal for ImmunoTherapy of Cancer. 2023;11(9):e006782. doi: 10.1136/jitc-2023-006782.

Chen L, Shi V, Wang S, Sun L, Freeman R, Yang J, Inkman MJ, Ghosh S, Ruiz F, Jayachandran K, Huang Y, Luo J, Zhang J, Cosper P, Luke CJ, Spina CS, Grigsby PW, Schwarz JK, Markovina S. SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production. Journal of Clinical Investigation. 2023;133(15):e163841. doi: 10.1172/JCI163841.

Spina CS, Tsuruoka C, Mao W, Sunaoshi M, Chaimowitz M, Shang Y, Welch D, Wang YF, Venturini N, Kakinuma S, Drake CG. Differential immune modulation with carbon-ion versus photon therapy. International Journal of Radiation Oncology, Biology, Physics. 2021;109(3):813–818. doi: 10.1016/j.ijrobp.2020.09.053.

Aggen DH, Ager CR, Obradovic AZ, Chowdhury N, Ghasemzadeh A, Mao W, Chaimowitz MG, Lopez-Bujanda ZA, Spina CS, Hawley JE, Dallos MC, Zhang C, Wang V, Li H, Guo XV, Drake CG. Blocking IL1 beta promotes tumor regression and remodeling of the myeloid compartment in a renal cell carcinoma model: multidimensional analyses. Clinical Cancer Research. 2021;27(2):608–621. doi: 10.1158/1078-0432.CCR-20-1610.

Spina CS, Drake CG. Mechanisms of immune modulation by radiation. Seminars in Radiation Oncology. 2021;31(3):205–216. doi: 10.1016/j.semradonc.2021.02.001.

Horowitz DP, Wang YF, Lee A, Riegel AC, Pasetsky J, Elliston C, Spina C, Deutsch I, Ghiassi-Nejad Z, Yuan Y, Price M, Kachnic LA. Practical approach to computed tomography guided online adaptive radiation therapy for abdominopelvic tumors. Practical Radiation Oncology. 2025;15(2 Suppl):S1879850025000621. doi: 10.1016/j.prro.2025.02.011.

Valencia Lozano I, Buss E, Spina CS, Horowitz DP, Kachnic LA, Price M, Wang YF, Munbodh R. Quantification and dosimetric impact of intra‐fractional bladder changes during CBCT‐guided online adaptive radiotherapy for pelvic cancer treatments. Journal of Applied Clinical Medical Physics. 2025;26(3):e70074. doi: 10.1002/acm2.70074.

Rayn K, Deutsch I, Jeffers B, Lee A, Lavrova E, Gallitto M, Mayeda M, Hwang M, Yu J, Spina C, Koutcher L. Multiparametric MRI as a predictor of PSA response in patients undergoing stereotactic body radiation therapy for prostate cancer. Advances in Radiation Oncology. 2024;9(3):101408. doi: 10.1016/j.adro.2023.101408.

Wang YF, Price MJ, Elliston CD, Munbodh R, Spina CS, Horowitz DP, Kachnic LA. Enhancing safety in AI-driven cone beam CT-based online adaptive radiation therapy: development and implementation of an interdisciplinary workflow. Advances in Radiation Oncology. 2024;9(3):101399. doi: 10.1016/j.adro.2023.101399.

Cheng EY, Bender DA, Heilbroner SP, Wang TJC, Shu CA, Hyde B, Spina CS, Cheng SK. Rates of immunosuppressive treatment and hospitalization after checkpoint inhibitor therapy in cancer patients with HIV. Available at SSRN. 2022. doi: 10.2139/ssrn.4064961.

Bender DA, Heilbroner SP, Wang TJC, Shu CA, Hyde B, Spina CS, Cheng SK. Increased rates of immunosuppressive treatment and hospitalization after checkpoint inhibitor therapy in cancer patients with autoimmune disease. Journal for ImmunoTherapy of Cancer. 2020;8(2):e001627. doi: 10.1136/jitc-2020-001627.

Hsieh K, Hwang ME, Estevez-Inoa G, Save AV, Saraf A, Spina CS, Cheng SK, Wang TJC, Wu CC. Temporalis muscle width as a measure of sarcopenia correlates with overall survival in patients with newly diagnosed glioblastoma. Journal of Radiation Oncology. 2019;8(4):379–387. doi: 10.1007/s13566-019-00408-9.

Spina CS. Androgen deprivation therapy and radiation therapy for prostate cancer: the mechanism underlying therapeutic synergy. Translational Cancer Research. 2018;7(Suppl 6):S695–S703. doi: 10.21037/tcr.2018.05.42.

Black PJ, Smith D, Chaudhary KR, Xanthopoulos EP, Chin C, Spina CS, Hwang M, Mayeda M, Wang YF, Connolly EP, Wang TJC, Wuu CS, Hei T, Cheng SK, Wu CC. Adaptive deformable registration and fusion for fractionated stereotactic radiosurgery using a small animal irradiator. International Journal of Radiation Oncology, Biology, Physics. 2018;102(3 Suppl):e542. doi: 10.1016/j.ijrobp.2018.07.1514.

Hsieh K, Hwang M, Estevez-Inoa G, Saraf A, Spina CS, Smith D, Wu CC, Wang TJC. Temporalis muscle width as a measure of sarcopenia independently predicts overall survival in patients with newly diagnosed glioblastoma. International Journal of Radiation Oncology, Biology, Physics. 2018;102(3 Suppl):e225. doi: 10.1016/j.ijrobp.2018.07.771.

Black PJ, Smith DR, Chaudhary K, Xanthopoulos EP, Chin C, Spina CS, Hwang ME, Mayeda M, Wang YF, Connolly EP, Wang TJC, Wuu CS, Hei TK, Cheng SK, Wu CC. Velocity-based adaptive registration and fusion for fractionated stereotactic radiosurgery using the small animal radiation research platform. International Journal of Radiation Oncology, Biology, Physics. 2018;102(4):841–847. doi: 10.1016/j.ijrobp.2018.04.067.

Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, De Soysa Y, Cahan P, Theißen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ. Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature. 2016;535(7611):246–251. doi: 10.1038/nature18632.

Jasuja R, Costello JC, Singh R, Gupta V, Spina CS, Toraldo G, Jang H, Li H, Serra C, Guo W, Chauhan P, Narula NS, Guarneri T, Ergun A, Travison TG, Collins JJ, Bhasin S. Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate‐sparing anabolic therapy. Aging Cell. 2014;13(2):303–310. doi: 10.1111/acel.12174.

Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes & Development. 2014;28(9):971–982. doi: 10.1101/gad.237149.113.

Torisawa YS, Spina CS, Mammoto T, Mammoto A, Weaver JC, Tat T, Collins JJ, Ingber DE. Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro. Nature Methods. 2014;11(6):663–669. doi: 10.1038/nmeth.2938.

Morones-Ramirez JR, Winkler JA, Spina CS, Collins JJ. Silver enhances antibiotic activity against gram-negative bacteria. Science Translational Medicine. 2013;5(190):190ra81. doi: 10.1126/scitranslmed.3006276.

Modi SR, Lee HH, Spina CS, Collins JJ. Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome. Nature. 2013;499(7457):219–222. doi: 10.1038/nature12212.

Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells. Science Translational Medicine. 2013;5(192):192ra85. doi: 10.1126/scitranslmed.3006055.

Brynildsen MP, Winkler JA, Spina CS, MacDonald IC, Collins JJ. Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production. Nature Biotechnology. 2013;31(2):160–165. doi: 10.1038/nbt.2458.

Maehr H, Uskokovic M, Adorini L, Penna G, Mariani R, Panina P, Passini N, Bono E, Perego S, Biffi M, Holick M, Spina C, Suh N. Calcitriol derivatives with two different side chains at C-20. The Journal of Steroid Biochemistry and Molecular Biology. 2007;103(3–5):277–281. doi: 10.1016/j.jsbmb.2006.12.001.

Spina CS, Ton L, Yao M, Maehr H, Wolfe MM, Uskokovic M, Adorini L, Holick MF. Selective vitamin D receptor modulators and their effects on colorectal tumor growth. The Journal of Steroid Biochemistry and Molecular Biology. 2007;103(3–5):757–762. doi: 10.1016/j.jsbmb.2006.12.040.

Spina CS, Tangpricha V, Uskokovic M, Adorinic L, Maehr H, Holick MF. Vitamin D and cancer. Anticancer Research. 2006;26(4A):2515–2524. Available from: https://ar.iiarjournals.org/content/26/4A/2515

Spina C, Tangpricha V, Yao M, Zhou W, Wolfe MM, Maehr H, Uskokovic M, Adorini L, Holick MF. Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its gemini analogs. The Journal of Steroid Biochemistry and Molecular Biology. 2005;97(1–2):111–120. doi: 10.1016/j.jsbmb.2005.06.003.

Tangpricha V, Spina C, Yao M, Chen TC, Wolfe MM, Holick MF. Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice. The Journal of Nutrition. 2005;135(10):2350–2354. doi: 10.1093/jn/135.10.2350.

Tangpricha V, Turner A, Spina C, Decastro S, Chen TC, Holick MF. Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density. The American Journal of Clinical Nutrition. 2004;80(6):1645–1649. doi: 10.1093/ajcn/80.6.1645.